4 Important Considerations for Laser Diffraction Methods

Written by Twitter Secrets on . Posted in Analytical validation definition, Nanotechnology, Particle size analysis

Mercury porosimetry testing

The idea behind science and research is to further our information about a topic. The researched results then allow us to make advancements and further our knowledge base about specific topics. Scientific research often begins at the lowest level. Analytical development scientists need to see the smallest molecules and atoms of an item, to truly understand how they function and how they can then be improved upon. This extremely small size can be difficult to view with the human eye, and so a variety of tools are used.

Ability to view the smallest of measurements
The specific measurement tools that are used in scientific research need the ability to view the smallest of the make ups. A millimeter itself can be difficult to view, but sometimes we need to see fractions, up to thousandths of a millimeter. Standard laser diffraction can be used for particles in the size range from about 400 nm up to a few millimeters. For newer equipment, the size range is often extended down to the lower nanometer range by combining laser diffraction with other techniques, such as measurement of scattering intensities in different directions. As research continues to improve, so will the tools and depths we can view, allowing up to further advance small particle measurement research.

Laser diffraction method used in pharmaceuticals
Analytical development definition expands to many different industries. You will find a variety of fields that benefit from both laser diffraction measuring and specific analytical testing laboratory tools. There are many reasons to expand abilities to see smaller into pharmaceuticals. Drug therapy is one of the most common forms of medical treatment or symptom control today. The more that can be identified about specific medications and their functions will increase the ability to treat other diseases and illnesses.

Biodegradable polymers such as polylactic acid (PLA) are frequently studied as potential carriers for controlled release formulations of active pharmaceutical. Since PLA nanoparticles are often in the range of 50 to 500 nm using both laser diffraction and dynamic light scattering (DLS) could be used for size analysis, but laser diffraction has the advantage of also being able to detect aggregates.

Routine steps involved in particle size analysis
Regardless of the specific measurement tools used for BET analysis and BET surface area analysis services, the same specific and routine steps are often used. In general, particle size analysis by the sieving or laser diffraction method includes the following steps, sampling of bulk powders, sub sampling of bulk samples for specimen, specimen preparation or dispersion, instrument set up and verification, size measurements, data analysis and interpretation, and report of size results. The careful completion of each one of these steps is often important to obtaining consistent and accurate results among various trials.

Reduction in error and increase in consistency
The goal of any scientific project is to obtain accurate results. Simply measuring something once often does not product very effective or accurate of results. For this reason, multiple tests are often needed. The results are carefully evaluated for each test and then compared to one another. It is also best to remain consistent with the tools used for measuring. Changing measurement properties or the specific steps taken to measure something puts too many extra factors into the equation, making it difficult to achieve consistency. If all of these different factors are not consistent, the results will be thrown out, and the research is for nothing.

Scientists are constantly looking not only for new research, but also for new ways to conduct that research. Newer tools that allow a scientist to see smaller versions of a test subject can improve the amount of information about that item, allowing us to make improvements and suggestions. There are different tools and methods to measure, but the specific steps and recording requirements often remain consistent.

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